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We prepared sterically stabilized liposomes with encapsulated recombinant human TG1 (rhTG1) and equipped with a highly cationic lipopeptide vector to mediate cellular uptake.
However, Chung et al. showed that the surface charge of mesoporous silica particles could mediate cellular uptake rate or even cellular uptake route of the particles [29].
Although low expression of the nucleoside transporters hENT1 and hCNT3 that mediate cellular uptake of gemcitabine has been linked to gemcitabine resistance, the mechanisms regulating their expression in the PDAC tumor microenvironment are largely unknown.
In other cases, HSPGs mediate cellular uptake and catabolism of selected ligands [10], or sequester polypeptides to the ECM and cell surface as an inactive reservoir [11] [15].
Current phage biopanning methods focus on identifying peptides that bind to and/or mediate cellular uptake.
SLC1A family transporters mediate cellular uptake of glutamate, driven by 3Na+,1H+ cotransport, 1 K+ counter-transport.
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Kang, J. et al. PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid.
Qiu, Y. et al. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods.
Transferrin receptor mediates cellular uptake of iron, and the expression on cells reflects iron needs and erythropoietic activity.
Ct-OATP1B3 is an mRNA variant of the liver-specific OATP1B3 (which is hereafter referred to as the liver-type OATP1B3, Lt-OATP1B3) that mediates cellular uptake of a variety of endogenous compounds (e.g., cholecystokinin-octapeptide sulfated, CCK-8, or estradiol-17β-D-glucuronide, E2G), as well as drugs (e.g., paclitaxel or imatinib) at the basolateral membrane of hepatocytes [8],[9].
Recent studies showed that CD36 mediates cellular uptake of long chain fatty acids and their intestinal absorption in mice [31].
More suggestions(15)
mediate cellular processing
mediate cellular signaling
mediate cellular attachment
mediate cellular senescence
mediate cellular physiology
mediate cellular cholesterol
mediate cellular differentiation
mediate cellular apoptosis
mediate cellular stress
mediate cellular function
mediate selective uptake
mediate cellular response
mediate cellular efflux
mediate cellular transformation
mediate cellular signalling
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