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Integrins are the major receptors that mediate cellular adhesion and reaction to the ECM and thus play essential roles in regulating cell migration, growth, division, survival, differentiation, and apoptosis.
Furthermore, CfLec-2 could mediate cellular adhesion to enhance encapsulation of hemocytes, which was similar to CfLec-1, but it could not mediate phagocytosis [53].
CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration.
These proteins collectively mediate cellular adhesion to extracellular matrix (ECM) and modulate cell proliferation, migration, invasion, and survival by activating intracellular signaling pathways [ 11].
Claudins, the major tight junction transmembrane proteins, are members of the tetraspanin protein superfamily that mediate cellular adhesion and migration [ 64].
We also were not surprised to find alterations in the expression of genes that contribute to malignant transformation and inflammation, including those that mediate cellular adhesion, stromal degradation or invasion (metalloproteinases), and the pathogenesis of leukemia [ 57- 60].
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Mg2+ ions also play an important role in mediating cellular adhesion.
We hypothesized that EGF receptor and integrin signalling pathways interact in mediating cellular adhesion and invasion in pancreatic cancer, and that invasiveness correlates temporally with detachment from extracellular matrix.
In addition, u-PA/u-PAR mediates cellular adhesion to the ECM protein, vitronectin directly through integrin-independent, high-affinity interaction between u-PAR and vitronectin, and indirectly through function modifying lateral associations with integrin family members (Xue et al, 1997; Degryse et al, 2001).
This fusion protein coating, which mediates cellular adhesion through the E-cadherin component, has been reported to support long-term culture of teratoma-forming hPSCs in combination with a range of chemically defined media and has been commercialised as StemAdhereTM[ 10, 43].
Integrins are dimeric adhesion receptors that mediate cellular attachment to the extracellular matrix (ECM) or to adjacent cells.
More suggestions(15)
mediate cellular resistance
mediate cellular communication
mediate cellular processing
mediate cellular signaling
mediate strong adhesion
mediate cellular senescence
mediate cellular cholesterol
mediate cellular uptake
mediate cellular differentiation
mediate cellular stress
mediate cellular apoptosis
mediate cellular internalization
mediate cellular function
mediate cellular response
mediate cellular transformation
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