Sentence examples for mediate cellular internalization from inspiring English sources
We included only one VEGF isoform, VEGF165; its transport includes diffusion, protease interactions, and binding to HSPGs and VEGFRs (which mediate cellular internalization of VEGF).
It is therefore necessary to chemically modify PNA by fusion with cell penetrating peptides or formulation into delivery systems that can mediate cellular internalization and cytoplasmic release.
The peptide can increase the permeability of tumor cells, mediate cellular internalization and extravasation, and enhance deep tissue penetration to improve the imaging sensitivity and therapeutic efficacy mediated by integrins and neuropilin-1 (NRP-1) receptors [ 3, 23, 30].
This kind of disulfide-based cyclic RGD peptide, called iRGD (CRGDK/RGPD/EC), can interact with both integrin and neuropilin-1 receptors to mediate cellular internalization to improve imaging sensitivity [ 3].
Furthermore, The PEG layer would detach from the NPs due to the up-regulated extracellular MMP2 and MMP9 in tumors, resulting in the exposure of folate to enhance the cellular internalization via folate receptor mediated endocytosis, which accelerated the release rate of CPT in vivo.
Driven by the recent literature on hormetic phytochemicals, we focused our attention on curcumin, which is known to mediate beneficial effects on health even for a better understanding of its cellular internalization, intracellular localization and mode of action.
Finally, one must consider the mechanism of cellular internalization, and investigators should attempt to target pathways and incorporate vector functionalities that will mediate trafficking to the subcellular compartment that is optimal for activity of the nucleic acid cargo.
Figure 8 Cellular internalization efficacy of N Chitosan-DMNPs.
Cellular internalization required sulfated proteoglycans and cholesterol.
Additionally, the cellular internalization of the radiofluorinated ligands was determined.
MR imaging and fluorescence microscopy confirmed cellular internalization of N Chitosan-DMNPs.
