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Phosphorylated VEGFRs are considered to mediate cellular functions by activating various types of signaling pathways.
Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes.
It is becoming increasingly clear that lipid droplets mediate cellular functions other than fat storage and mobilization relevant for energy homeostasis.
This could signify that most complex variations mediate cellular functions that are important for strain fitness independent of the growth conditions.
It is worth noting that eight type IV pilus assembly proteins belonged to this group including pil C, D, G, I, M, N, O and P. Type IV pili have been implicated in the pathogenicity of gram negative bacteria, and mediate cellular functions such as twitching motility, host-cell adhesion and cell signaling [ 30].
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Integrins directly associate with uPAR to mediate cellular function (Wei et al, 1999).
Myosin II motor proteins are believed to be involved in mediating cellular functions by undergoing filament assembly in the cells.
OPN, a secreted phosphoprotein, exists both as an immobilized ECM molecule in mineralized tissues and as a cytokine that mediates cellular functions involved in inflammation and ECM remodelling [31].
Therefore, effector proteins such as AES and/or LRP6-ICD which are capable of modulating TCF/LEF-1 activity through long Groucho/TLE and/or β-catenin, have the potential to influence Wnt pathway mediated cellular functions such as proliferation/differentiation.
In addition to signaling by the NO molecule alone, ROS including superoxide, hydrogen peroxide, and peroxynitrite are also involved in mediating cellular functions.
The inositol ring can be phosphorylated at the D3, D4 or D5 position to produce a set of seven distinct phosphorylated derivatives, which are preferentially located in various cellular membranes or microdomains, specifying their identity, and mediating cellular functions by recruiting various effector proteins with specialized lipid-binding domains [ 1].
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