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The effects of somatostatin are mediated via a family of cell-surface receptors that differ in their tissue distribution, pharmacological properties and intracellular response mediators, suggesting that they mediate different functions of the peptide.
In a cell, specific domains of the protein could mediate different functions.
Different members of the AtNPR family appear to mediate different functions in plant defense.
These two distinct domains, which are both required for proper chromosome segregation and inheritance, mediate different functions.
However, the α and β receptors for PDGF mediate different functions: the β receptor is important in mediating pro-fibrotic cell migration, whereas the α receptor inhibits migration.
Timing of transcription could be an alternative mechanism by which CIRs of different subgroups mediate different functions, therefore we investigated the transcriptional pattern of these genes throughout the intra-erythrocytic developmental cycle (IDC) in P. chabaudi.
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3) Different modulation states might exist in other frequency bands mediating different functions in the brain.
In the nucleus it mediates different functions, such as stabilization of nucleosomes, DNA repair and recombination, and transcription.
The pleiotropic effects of TNF reflect the complexity of a system involving both transmembrane and soluble forms of TNF and two receptors mediating different functions, as well as effects that depend on the timing and localisation of TNF production [ 4].
Multiscale modeling/simulations attracts an increasing number of neuroscientists to study how different levels of organization (networks of neurons, cellular/subcellular levels) interact with each other across multiple scales, space and time, to mediate different brain functions.
Similar to phosphorylation, acetylation has been shown to both promote and decrease FOXO transcriptional activity and to mediate different biological functions of FOXOs [ 36, 37].
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