The 14-3-3 14-3-3 14-3-3functisoformscanpensate functionallyer, but compensateediate specifor ceachlar functiotherthe σ isoform for example is implicated in cancer and cell cycle regulation [ 9, 12], whereas the isoforms ε and ζ are highly expressed in postmitotic cells of the butin [ 13].
These Nox subtypes present in distinct subcellular compartments, respond to different agonists, and often mediate specific cellular functions [ 19, 20, 24- 26].
Chemokines, also known as chemotaxic cytokines, are secreted proteins that function as chemoattractants, mediating the recruitment of various subsets of leukocytes to sites of tissue damage to mediate specific immunological functions (1, 2).
Response to stimuli and regulation of transcription are believed to happen through perception of PSY1 peptide by the receptor PSY1R as extracellular signals mediate specific cellular functions by triggering a signaling cascade that result in modulation of transcription factor activity [ 25].
As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor combinations mediate specific cellular functions.
The architecture within which cells reside is key to mediating their specific functions within the body.
Some of the purified factors harbor extensive sets of unique interacting proteins that may mediate their specific function in ESCs.
3D domain swapping was proposed as an important mechanism to explain the evolution of proteins from monomeric to oligomeric conformations to mediate a specific function.
Another miRNA, miR-9/9*, has recently been linked to the molecular pathways of neural differentiation, and provides a good example in which several mechanisms of epigenetic regulation feedback on one another to mediate a specific function.
The restricted expression of KNOLLE from G2/M-phase onward and its accumulation at the cell plate likely mediate its specific function during cytokinesis (Lauber et al, 1997; Müller et al, 2003; Reichardt et al, 2007).
