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Each S1PR is coupled to specific G proteins, which mediate unique functions.
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Teleologically, the requirement for such a diverse group of 'master regulators' seems evolutionarily cumbersome, and emerging evidence indicates that these transcription factors do in fact mediate unique and specialized functions, suggesting the existence of higher-order 'masters' that truly direct and coordinate EMT programs.
However, since TNF mediates unique physiologic functions, in particular those related to host defense, TNF blockade may result in unwanted consequences.
PKCs are sophisticated kinases with multiple activation modes, and despite a high degree of sequence homology, the PKC isoforms exhibit a significant degree of non-redundancy, with individual isoforms mediating unique cellular functions by binding and phosphorylating distinct protein substrates [37].
Their unique functions are mediated by priming the naïve T cells and cross-presenting various antigens.
Thus, a helix replacement mechanism directs metavinculin's unique functions.
These three adhesions types have unique functions in filopodium dynamics.
American higher education performs a unique function.
Marketing is the distinguishing, unique function of the business".
This causes the tet operon to loose its unique function.
Bone resorption is the unique function of osteoclasts.
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