Cytochrome P450 (CYP) monooxygenase superfamily mediates numerous functions in fungi.
In addition, growth factors, cytokines and chemokines mediate numerous important cellular functions.
Interactions between carbohydrates and proteins mediate numerous important biological functions, such as signal transduction, cell adhesion, host pathogen recognition, and the immune response.
NO is a cellular second messenger that mediates numerous biological functions such as vasodilation, muscle contractility [8], [9], anti-apoptosis [10], heart rate, and heart development [11], [12].
The gp130 receptor is ubiquitously expressed in tissues and mediates numerous homeostatic functions, including immune response, inflammation, bone metabolism, and hematopoiesis [ 27].
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase and scaffolding protein that mediates numerous cellular functions, including adhesion, migration and invasion [ 9].
Polyamines mediate numerous cellular and physiological functions.
RNA-binding proteins (RBP) interact with transcripts to mediate numerous aspects of RNA metabolism [ 54] and function as chaperones that facilitate the long-distance transport of phloem-mobile mRNAs [ 20].
PACAP displays numerous functions in cells of neuronal and non neuronal origin and functional VIP/PACAP receptors have been demonstrated on PMNs, mediating Ca2+- dependent pro-inflammatory activities through the activation of multiple regulatory pathways [71].
Integrins mediate numerous intracellular signaling pathways, such as calcium channels, kinases, and phosphatases, and also recruit intracellular signaling reagents, influencing cellular functions such as motility and tissue invasion.
