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To date, our data are merely consistent with the hypothesis that early life events can alter the epigenetic status of genes that mediate neural functions, and thus contribute to individual differences in the risk for suicide.
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The PBDE-induced changes in TH-regulated gene transcripts seen here indicate that neurogenesis and brain development may be impacted by PBDE exposure, and they highlight the need for future investigations into how PBDEs influence TH-mediated neural function.
Neurons that release serotonin as a neurotransmitter project to most regions of the central and peripheral nervous system and mediate diverse neural functions.
We predict that this domain has functional significance and may mediate some of the neural functions already indicated for Sho.
The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate neural development and immune system functioning through cell-cell and cell-matrix interactions.
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are novel tools for the dissection of circuitry mediating behavior and neural function.
Although the function of Hes-1 in Neuro2a remains unknown, we hypothesize that the AhR might mediate neural development and differentiation through Hes-1 in the same manner as other members of the bHLH family gene network.
The function of LRRK2 remains largely elusive but G2019S mutations enhance its kinase activity, which may mediate neural toxicity [ 72].
We alter one another's physiology and neural functions.
It can be something they might really ruminate on, he adds, now that their higher neural functions are active again.
These might mediate neural events as a result of alternative splicing.
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