Chemokines, also known as chemotaxic cytokines, are secreted proteins that function as chemoattractants, mediating the recruitment of various subsets of leukocytes to sites of tissue damage to mediate specific immunological functions (1, 2).
IL-17A and IL-17F mediate their immunological function by inducing pro-inflammatory cytokine, anti-pathogenic peptide and chemokine secretion by responder cells.
While these signaling pathways mediate the anti-tumor and immunological functions of cytokines in the periphery, increasing evidence has also indicated an important role in a range of neurological conditions ranging from depression to Parkinson's and Alzheimer's disease [ 95- 97].
Through specific interactions with distinct types of Fcγ receptors (FcγRs), the Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and adaptive responses.
T cells express receptors for neuropeptides that mediate immunological activities.
Kumanogoh, A. & Kikutani, H. Immunological functions of the neuropillins and plexins as receptors for semaphorins.
Champagne, E., Martinez, L. O., Collet, X. & Barbaras, R. Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions.
The immunological functions of most of the interleukins are known to some degree.
Antibody complementarity determining region (CDR) H3 loops are critical for adaptive immunological functions.
Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions.
