Sentence examples for major cellular function from inspiring English sources

As the major cellular function of Smad7 is to inhibit TGF-β signaling, we analyzed whether deletion of Smad7 is associated with an enhancement of Smad2/3 phosphorylation in the mouse liver.

We thus determined whether the PDK1-IFPC::IFPN-AKT1 complex could promote cell viability, a major cellular function of the endogenous PDK1 and AKT, when particular PI3K pathway components were inhibited.

4) Is the β-cell similar or different from most tissues in term of metabolic activation, specifically whether it is primarily governed by a "push" (fuel substrate driven) process, rather than a "pull" mechanism secondary to enhanced activation of its major cellular function.

The presumed major cellular function for each down or up-regulated gene was identified using annotation data from the PubMed database, and/or the Online Mendelian Inheritance in Man (OMIM) database.

Prior to the 1990's, alpha-crystallin was thought to be a structural protein whose major cellular function was to produce a dense solution necessary for the refraction of light in the lens.

A large number of miRNAs are involved in almost every major cellular function (Cowland et al, 2007) and as a consequence, deregulation of miRNAs has also been linked to a broad variety of cancers (Calin et al, 2002, 2005; Michael et al, 2003; Takamizawa et al, 2004; Iorio et al, 2005; Lu et al, 2005; Mattie et al, 2006; Murakami et al, 2006; Volinia et al, 2006).

All these genes play a role in major cellular functions such as proliferation, activation and apoptosis and the functional network established for 8 of the 9 genes reveals that 5 of the networked genes (AP1, CD3, CD247, NFATC2 and PIK3CA) are part of the glucorticoid receptor signaling pathway.

mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase involved in regulating major cellular functions including growth and proliferation.

Genes contributing to these major cellular functions are shown in Table 2.

It is not surprising therefore that photosynthesis was one of the major cellular functions represented in the CTR.

FAK regulates major cellular functions including migration, spreading, cell cycle progression and survival in numerous cell types [ 21].