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After understanding the mechanism of interaction between aspirin and the vascular endothelium, Vane proposed assigning a major physiological function to the vascular endothelium which then became a pharmacological target for new drugs.
A major physiological function for PrPC is still elusive and it is becoming increasingly clear that PrPC may play a pleiotropic role in a variety of cellular functions.
BAT is of particular importance in neonates, small mammals (such as mice) in cold environments, and animals that hibernate, because its major physiological function is to dissipate stored energy as heat.
The major physiological function is to prevent extracellular calcification [ 8].
The major physiological function of plasminogen system (PAI-1, tPA, plasminogen, and others) is to regulate physiological fibrinolysis.
Notably, sAPP α has neuroprotective and memory enhancing properties [ 10, 11], hypothesizing that sAPP α might mediate a major physiological function of APP [ 12].
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TSPO is implicated in major physiological functions and functionally associated with other proteins such as the voltage-dependent anionic channel, also designated as mitochondrial porin.
Our novel idea in this regard is resuscitation of BG loop in order to maintain its major physiological functions, and at the same time raising the threshold in order to weaken the internal disturbances.
Cilia have two major physiological functions.
It is thus necessary to improve our knowledge of the major physiological functions and their interactions.
Hence, intestinal microbiota has a strong impact on the control of numerous major physiological functions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com