Lysosomes are major cellular degradative organelles, involved in turnover of molecular cargo from both autophagic and endocytic pathways, and in AD, disturbed lysosomal degradation is presumed to be of key importance in aberrant AV turnover.
Autophagy and the UPS are the two major cellular protein degradation pathways.
Autophagy is a major cellular lysosomal degradation pathway of bulk material, and levels are known to fall with age.
The ubiquitin proteasome system is one of the major cellular machineries for protein degradation.
The proteasome is one of the two major cellular pathways of cellular protein degradation.
We have characterized the two major cellular pathways involved in protein degradation in MCF10A and MCF7 cells.
The proteasome is the major cellular protease responsible for intracellular protein degradation, having an impaired function during aging.
Autophagic and proteasomal degradation constitute the major cellular proteolysis pathways.
By employing electron, confocal and time-lapse microscopy and pharmacological inhibition of cellular organelles, we identified five consecutive entosis stages and defined the individual roles of the major cellular organelles contributing to invasion and eventual degradation of internalized cells.
