It is thus not unexpected that a major cellular protein phosphatase, PP2A, which counteracts the survival function of kinases, is activated by caspases.
Autophagy and the UPS are the two major cellular protein degradation pathways.
TRX, a major cellular protein disulfide reductase, modulates protein structure and aggregation by cross-linking proteins with disulfides and reduction of protein cysteine residues.
At the posttranslational level, RIF treatment reduces AGE formation on major cellular proteins that control metabolism and support musculature.
NS3 and NS5 proteins of Flavivirus were studied using yeast two-hybrid assay that is able to screen for interacting proteins, and results indicated that NS3 or NS5 protein interacts with many major cellular proteins such as vimentin and myosin, but no further studies were done to identify the mechanism of these interactions [ 67].
CD26 is the major cellular anchoring protein for ecto-ADA and has an intrinsic dipeptidyl peptidase activity [ 15], therefore we examined the functional consequence of increased CD26 on HT-29 cells directly in parallel with measurements of the surface abundance of CD26 (Fig. 2).
Trypanosomes and other microbial pathogens can evade the immune system by periodically moving new genetic information from a "silent" gene to a highly transcribed locus that encodes a major cellular coat protein; this process is often initiated by a directed double strand break (Deitsch et al., 2009; Vink et al., 2012).
Since no major cellular organelle proteins, such as cytochrome c from mitochondria, glucose-6-phosphatase from endoplasmic reticulum, or ribosomal proteins, were detected, it seems possible that these proteins, of epithelial origin, may arise as part of the secretion process from the cells, rather than a generalized disruption process.
It should also be appreciated that the current analysis describes only the major FLS cellular proteins.
The proteasome is one of the two major cellular pathways of cellular protein degradation.
Eukaryotic genes produce a number of alternative isoforms that are commonly believed to be a major source of cellular protein diversity61,62,63.
