Protein synthesis, apoptosis, cellular movement, growth and proliferation were the main cellular functions associated with the modulated genes.
Data mining analysis showed that protein synthesis, apoptosis, cellular movement, growth and proliferation were the main cellular functions significantly associated with the modulated genes (p < 0.05).
Unexpectedly, the global analysis of gene functions reveals that two main cellular functions, protein metabolism and chromatin structure/transcriptional regulation, could be deregulated by v-ErbA.
Src family kinase (SFK) proteins regulate four main cellular functions that ultimately control the behaviour of transformed cells: cell proliferation, adhesion, invasion, and motility (Summy and Gallick, 2003; Yeatman, 2004).
The 10%% of the highest constitutively expressed genes for all carbohydrate treatments (163 genes) were assigned Clusters of Orthologous Groups (COG) categories [ 27] and emphasized main cellular functions of growth and energy turn-over.
The use of functional annotations (mainly Gene Ontology (GO) annotations) allowed us to find that many v-ErbA repressed target genes are involved in two main cellular functions: chromatin structure/transcriptional regulation and protein metabolism.
Genes identified through microarray analysis (focus genes), network score (probability of network being assembled by chance alone), and main cellular functions of the network are listed in Table 5.
Organelle degradation by autophagy can serve three main cellular functions, namely nonselective degradation, e.g., under nutrient depletion conditions to recycle cellular material; selective degradation of redundant organelles; and constitutive degradation to remove exhausted organelles as a mode to continuously rejuvenate the organelle population (Aksam et al. 2007).
Protein synthesis, apoptosis, cellular movement, growth and proliferation are the main significant cellular functions (p < 0.05) that are associated to the modulated genes.
