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Bone marrow mesenchymal stem cells (MSCs) have become the main cell source for bone tissue engineering.
Mesenchymal stem cells (MSCs) from bone marrow are main cell source for tissue repair and engineering, and vehicles of cell-based gene therapy.
Should hUCB-MSCs have a superior effect on wound healing as compared with fibroblasts, which are the main cell source in current cell therapy products for wound healing, they may possibly replace fibroblasts.
Although Schwann cells (SCs) and bone marrow derived mesenchymal stromal cells (BM-MSCs) are the main cell source for nerve tissue engineering, the clinical application is limited because of donor site morbidity, the invasive procedure, and the decreased number of SCs and BM-MSCs.
Interestingly, microglial cells, which are the main cell source of IL-1β in the brain [2], express P2X7R [11], [11].
Within the joint, chondrocytes may be the main cell source of NO, and iNOS expression is increased in human OA cartilage [ 29].
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This down-regulation of IL-12 production, presumably from its main cell sources was suggested to be due to the inhibitory effects of hemozoin [46].
MSCs from the subchondral bone are considered the main cell sources responsible for the repair of cartilage defects in the clinical procedure of microfracture [ 59].
Tissue engineering is a multidisciplinary field that is affected by three main agents including cell source, scaffold biomaterial, and biochemical agents.
In this review we describe, from an engineering perspective, progress in the field of liver tissue engineering, including three main aspects involving cell sources, scaffolds and vascularization.
The choice of stem cell source differed by main indication for all types of allogeneic HSCT.
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