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Over activation of ERK which is one of the main cell proliferation and survival factors.
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Tumour growth depends on two main factors, cell proliferation and cell death by apoptosis (Korsmeyer, 1992).
The main effect on cell proliferation and differentiation is attributable to the well known increase in cAMP levels in keratinocytes overexpressing VILIP-1, described in detail in our previous reports [3], [9].
The Ki-67 recently found to have interaction between CDK1 in nature structure and molecular biology [ 26] and CDK1 partake the main role in cell proliferation and even malignant transformation [ 10].
In conclusion, before all main factors affecting antler cell proliferation in vitro will be satisfactorily investigated, results of in vitro studies focused on hormonal regulation of antler growth should be taken with extreme caution.
The expression of proliferation marker Ki-67 is one of the main indicators of tumor cell proliferation and tumor grading.
Main tumor responsible mechanisms are cell proliferation and migration.
One of the main classes of regulators mediating cell proliferation and tumorigenesis are miRNAs [ 5, 9].
During wound-induced cell proliferation, the main focus of the healing process is to recover the wound surface.
The ovarian-derived steroid hormone estrogen is one of the main regulators of mammary epithelial cell proliferation and differentiation.
Wound healing is a very complicated process consisting of three main stages: local inflammation inhibition, cell proliferation, and tissue remodeling and organization.
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