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Integrins constitute the main cell surface adhesion receptors mediating cell-ECM adhesion.
The main cell surface proteoglycans carrying heparan sulfate in mammalian cells are syndecans and glypicans.
In the LPS signaling pathway, Toll-like receptor 4 (TLR4, CD284) is the main cell surface molecule inducing activation of NF-κB-dependent genes.
Main cell surface mediators of those cell matrix interactions are α-/ β-dystroglycan [ 41– 44], syndecans [ 29, 45– 47], and certain integrins being members of a large family of heterodimeric transmembrane proteins ([ 48– 51]; for general review: [ 19]).
CD44, the main cell surface HA receptor, binds to HA of six disaccharides and longer (Lesley et al, 2000), and mediates sHA-induced activation of signalling pathways in endothelial cells (Slevin et al, 2007; Matou-Nasri et al, 2009).
CD44 is the main cell surface receptor for hyaluronan or hyaluronic acid (HA) as well as OPN [ 215] and can also interact with other ligands, collagens, and matrix metalloproteinases (MMPs).
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Malignant mesothelioma and fibrosarcoma are aggressive tumors of mesenchymal origin, and they express a characteristic PG profile, in which syndecan-2 and -4 are the main cell-surface PGs [35], [36].
Finally, CD44, a main cell-surface receptor for hyaluronic acid, was downregulated in the group of good responders.
The main function of cell surface ATP synthase appears to act as proton transport [3].
Recently, Rusinok et al. published the first whole genome sequence of S. gallolyticus subsp. gallolyticus strain UCN34 and analyzed the main metabolic and cell surface features, particularly with regard to adaptation to the rumen and the virulence association of polysaccharide capsule, glucan mucopolysaccharides, different types of pili and collagen binding proteins [ 30].
We also confirmed that long and thin filopodia were growing from the main cell body on pSi surfaces, in addition to those protruding from lamellipodia (Figure 4A).
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prominent cell surface
main resonating surface
main membrane surface
main cell nutrient
main failure surface
main work surface
main fracture surface
main cell type
main groundwater surface
main binding surface
main respiratory surface
main bearing surface
main docking surface
main cell proliferation
main slip surface
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