Thus, the main issues that have to be handled in transcriptomic projects are study design, representative tissue source, logistics, and data interpretation.
Perhaps the most useful approach is based upon tracing the sources of the main tissues in the apical region.
Our main analyses are based on sample pairs with successfully assayed genotypes from both tissue sources.
Mesenchymal stem cells (MSCs) from bone marrow are main cell source for tissue repair and engineering, and vehicles of cell-based gene therapy.
Correlation of fetal insulin with fetal leptin levels suggests that fetal hyperinsulinemia, by stimulating white adipose tissue growth, the main leptin source, leads to higher leptin production in fetal adipose tissue [ 133].
In wounded tissues, the main source for TGFβ1 comes from degranulation of the platelets, in which TGFβ1 is the only isoform present in the α-granules (Assoian et al., 1983; Roberts and Sporn, 1996).
Bone marrow mesenchymal stem cells (MSCs) have become the main cell source for bone tissue engineering.
Although Schwann cells (SCs) and bone marrow derived mesenchymal stromal cells (BM-MSCs) are the main cell source for nerve tissue engineering, the clinical application is limited because of donor site morbidity, the invasive procedure, and the decreased number of SCs and BM-MSCs.
Blood monocytes are the main source of tissue macrophages recruited in response to exercise [ 24], and they participate in the repair, growth, and regeneration of muscles [ 25].
Synovial tissues appear a main source of synovial fluid miRNAs, but synovial fluid miR-223 reflects the influence of cells including MNCs infiltrating into synovial fluid.
