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Among the main cell adhesion molecules mediating these interactions are integrins [ 35- 37].
Besides its structural role, fibronectin is the main cell adhesion molecule, modulating many cellular activities.
Adhesion of hAMSCs, PA42-C4 finite clonal line, grown on the PCL film, was investigated by analysis of fibronectin, the main cell adhesion protein, and observation of cytoskeleton fibers, using LSCM.
Microscopic examination in LSCM of fibronectin, the main cell adhesion protein, of PA42-C4 gronn on PCL film for 7 days has permitted the verification of good adhesion of cells with intense staining localized over the entire cell surface, showing no qualitative differences with respect to PA42-C4 cells grown on PS, as control.
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Integrins constitute the main cell surface adhesion receptors mediating cell-ECM adhesion.
Processing maps to tailor the roughness, and wettability, the main parameters affecting cell adhesion characteristics of implants, were also determined.
Main features of cell adhesion and FN reorganisation evaluated after 1 h and after 5 days could be attributed to the anchorage strength of pre-coated FN layers at the polymer surface, which was, in turn found to be triggered by the type of modification applied.
This paper presents a systematic approach to discern the role of laser irradiation wavelength on the surface modification of PEEK under three laser wavelengths (λ = 1064, 532, and 355 nm) with the aim to determine the most adequate processing conditions to increase the roughness and wettability, the main parameters affecting cell adhesion characteristics of implants.
Integrins' main functions include cell adhesion, migration, and survival.
Performing a FEA through GeneTerm Linker, we obtained six metagroups that we labelled according to their main annotations: (Mg1) cell adhesion; (Mg2) voltage-gated ion/potassium channels; (Mg3) axon and cell projection; (Mg4) dendrite and neuronal cell body; (Mg5) synaptic neuroactive ligand-receptor interaction and (Mg6) MAPK signaling and Alzheimer.
The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblastoma is unclear.
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