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Exact(8)
Four macaques were euthanized at peak blood viremia (Figure 2A) [named below "primary-infected macaques"], and seven were euthanized during the chronic asymptomatic stage (Figure 2B).
In addition, SIV-infected macaques were euthanized at 42 days p.i. to examine cytokine and innate immune responses that are present during resurgence of virus replication.
Macaques were euthanized at 4 (6 macaques), 7 (11 macaques), 10 (12 macaques), 14 (6 macaques), 21 (12 macaques) and 42 (9 macaques) days p.i. in accordance with federal guidelines and institutional policies.
In this study a total of 55 SIV-infected macaques were euthanized at 4, 7, 10, 14, 21 and 42 days p.i. to examine the viral and cellular changes that occur from acute infection at 4 10 days p.i. to the early development of disease between 21 and 42 days p.i.
Several macaques were euthanized at regular intervals starting at 1 year postinoculation, and others were observed until clinical signs developed.
Therefore, both macaques were euthanized at day 12 and lymphocytes were harvested from several systemic tissues as well as the GALT.
Similar(52)
These lesions are very similar to HIV encephalitis, except that SIV-infected macaque brains often contains more lymphocytes; this is probably due to the fact that macaques are euthanized when they exhibit any clinical signs of disease, so the CNS is likely examined at an earlier stage of CNS disease progression [57].
Since all of the cynomolgus macaques involved in the epizootic were euthanized at the affected facility, the actual fate of the cynomolgus macaques was not clear, and some might have survived the infection.
Since the cynomolgus macaques at the facility where the RESTV epizootic occurred were euthanized, sequential serum specimens from each cynomolgus macaque were not available.
For study 2, macaques (group II) received 5 g BSE brain material on 1 occasion and were euthanized at regular intervals during the incubation period (macaques S9 S15, Table 2).
DNA was isolated for real-time PCR from selected tissues of macaques euthanized during acute disease and in those that were euthanized at the end of the study.
Related(20)
macaques were inoculated
macaques were supplied
macaques were grouped
macaques were assessed
macaques were left
macaques were prepared
macaques were housed
macaques were divided
macaques were performed
macaques were challenged
macaques were observed
macaques were stimulated
macaques were acquired
macaques were fasted
macaques were collected
macaques were scored
macaques were exposed
macaques were infected
macaques were elevated
macaques were subjected
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