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Furthermore, the macaques were grouped based on the genetic data so that each group comprised animals with an essentially similar genetically diverse background.
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However, EVs isolated from Old World monkeys (OWMs) (principally Asian macaques) are grouped into species A and B; a separate simian species (SEV-A); or are unassigned (EV-108, SV6, and EV-103) (3 ).
Macaques were kept in groups in cages and provided with food and water throughout the holding period.
A total of 14 Chinese-origin rhesus macaques were divided into four groups, three experimental groups and one control group.
During irradiation of each group, 2 macaques were sham irradiated (except for the groups receiving 1 Gy and 6.5 Gy. These two cohorts were irradiated on the same day and the same pair of macaques served as the sham controls for both).
Fourteen Indian rhesus macaques were stratified into comparable groups based on age, weight and sex.
Sixty flavivirus-naive rhesus macaques were randomly allocated into six groups (N = 10 per group).
To characterize the pathogenesis in cynomolgus macaques (Macaca fascicularis), groups of macaques were exposed to four different doses of aerosolized MPXV.
Macaques were housed in a social group, and behavioral changes were assessed on a daily basis by experienced animal care takers.
Six cynomolgus macaques were randomly divided into 2 groups and infected intramuscularly with 1,000 PFU of EBOV-Makona or EBOV-Mayinga.
In this study, four groups of cynomolgus macaques were exposed to increasing doses of aerosolized MPXV, with a particle size of 1 3 µm (Table 1).
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