Sentence examples for mutations with minimal from inspiring English sources

The method is based on the idea that recognition sites may correspond to localized regions with low-intensity energetic couplings with the rest of the protein, which allows them to undergo conformational changes, to be recognized by a binding partner, and to tolerate mutations with minimal energetic expense.

The first crystal structures of engineered FN3 molecules in complex with their targets have been solved, and structural studies of engineered FN3 have begun to reveal determinants of stability and to define zones that accept mutations with minimal trade-off between affinity and stability.

These predictions can reduce the requirement for experimental validation of low-priority candidate mutations with minimal changes in information content.

Fragmented DNA samples are loaded directly onto a flow cell and sequenced, thus detecting both small- and large-scale mutations with minimal sample preparation and high accuracy.

We have proposed combining multiple mutation extraction tools together by merging their results, and have shown that their combination results in substantially improved recall of mutations with minimal impact on precision, providing evidence of the complementary nature of the tools.

The former distinguishes between the smooth, unimodal distribution of a recently expanded population shaped by the accumulation of mutations with minimal lineage loss and the "ragged", multimodal distributions shaped by mutations in equilibrium with stochastic lineage loss [ 36- 38].

The targeting vector was designed to allow a substitution of the G309D mutation, with minimal disruption of the Pink1 gene.

Homma et al. have described a missense TARDBP mutation with minimal TDP-43 pathology [ 30], and it may be that the TDP-43 pathology in our case is also so subtle it has been missed.

In a preceding C. elegans spontaneous mutation accumulation experiment with minimal influence of natural selection, the spontaneous duplications ranged from 1 30 kb in length, with a median duplication span of 2 kb [ 8].

Tumours arising in PALB2 mutation carriers were associated with minimal sclerosis (odds ratio (OR)=19.7; 95% confidence interval (CI =6.0 64.6; P=5 × 10−7).

We have engineered both human IgG1 and IgG2 subtypes, with minimal point mutations, to form full-length bispecific human antibodies with high efficiency and in high purity.