Sentence examples for mutations with small from inspiring English sources

Mutations with small effect must be studied in large numbers of patients to be detectable.

These mutations with small effects are also much more frequent [ 1, 2].

Occasionally large-effect mutations with small or inconspicuous pleiotropic effects are observed as under strong selection.

It therefore has no effect on the conclusion that the strength of selection is approximately proportional to the expression level for mutations with small effect.

It remains largely unknown if such decay would stem from multiple mutations with small effects or rather involve few loci with major phenotypic effects.

In the long time scale, population size influences the probability of fixation of nonneutral mutations with small fitness effects (Ohta 1992).

Mutations with smaller fitness effects are expected to accumulate approximately at random in the MA lines.

While predictive power increases when more mutations with smaller effects contribute, predictability is retained down to relatively small number of mutations contributing to fitness differentials.

Observed dominance levels in other species are frequently somewhere in-between, where mutations with smaller effects tend to be closer to codominance [ 122- 130].

The simplification is based on the observation that (i) deleterious mutations with smaller effects have a higher probability of accumulating in the population than those with larger effects and (ii) mutations with large enough effects do not accumulate (see the 'wall of background selection' in Figure 1 and in [ 7]).

These observations match the expected pattern of diminishing returns, first proposed by Ronald Fisher in his Geometric Model of Adaptation (Fisher 1930) (FGM), which states that selection tends to act progressively more often on mutations with smaller phenotypic effects as populations approach a peak in the adaptive landscape.