Sentence examples for mutations with reduced from inspiring English sources

Binding assays revealed a constitutive up-regulation in these two nicotine mutations with reduced nicotine sensitivity.

Three GRN (1 known and 2 novel) mutations with reduced plasma protein levels were found associated to 3 distinct phenotypes (behavioral, affective, and delirious type).

BRAF mutations with reduced kinase activity are unlikely responsive to BRAF inhibitors.

Furthermore, the underlying genetics are complex, including mutations with reduced penetrance and interaction of several risk factors.

ATM mutations identified in A-T families can be classified in three categories; truncating mutations, mutations that lead to some expression of mutant protein that lacks kinase activity and missense mutations with reduced kinase activity (http://chromium.liacs.nk/lovd/).nk/lovd/

It is not known if polymorphisms or mutations with reduced functional activity in TLR4 or other innate immune sensors have an impact on the risk of inhibitors and hypersensitivity in haemophilia B patients as compared to our murine model [ 38].

As a result, in the IR regions of cycads, GC-biased mutations together with reduced substitution rates can best be explained by gBGC.

While TET2 mutations are associated with reduced overall survival in AML compared to patients with wild-type TET2, TET2 mutations in MDS and MPN patients promote progression to AML [ 68].

To identify the M. tuberculosis genes required for survival within DCs we infected primary human DCs with an M. tuberculosis transposon library and identified mutations with a reduced ability to survive.

Biallelic mutations in both NOP10 and NHP2 have been implicated in AR-DC, albeit in very rare instances and, like dyskerin mutations, have been linked with reduced TERC levels in DC patients [43,44].

Any pyrimidine in this position allowed high-affinity binding to SlmA, and mutation to guanine allowed binding but with reduced affinity.