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Orange residues indicate mutations with modest (
Three patients in the monotherapy arm without virological suppression acquired new resistance mutations with modest impact on LPV susceptibility.
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The small number of carriers reduced our ability to study the effects of the mutation on the development of CBC; and accordingly, we could not exclude the possibility that the CHEK2 *1100delC mutation is associated with modest increases in risk.
Dominant negative mutations with either R i > R i,min or with modest decreases in Δ R i, may be less likely to cause severe phenotypes, as a residual amount of the natural isoform continues to be expressed.
Mutations near both these pockets also confer resistance to omeprazole, a covalent inhibitor with modest activity [30].
Some genes, or some particular mutations, were described as associated with a high degree of sudden death (e.g. TNNT2 mutations; MYH7 p.Arg403Gln), modest LVH (TNNT2), or delayed cardiac expression (MYBPC3).
The leptin mutations arose spontaneously in the C57BL/6J mice, and resulted in the severe early-onset of obesity, hyperphagia, hyperinsulinemia, and insulin resistance with modest hyperglycemia.
Junior beamed with modest pride.
Clusters with modest branching account for the remaining 46%.
Biological evaluation of these was undertaken, with modest inhibition observed.
Beckett started the season with modest goals.
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CEO of Professional Science Editing for Scientists @ prosciediting.com