Sentence examples for mutations which led from inspiring English sources

The found that 21 separate "graffiti signatures" could account for 97% of the mutations which led to cancer.

In a previous recent work, we determined in vitro that MRS-deficiency accelerates the acquisition of mucA [30] and lasR [31], [32] mutations, which led us to the hypothesis that such an association may also be occurring in vivo.

These crypt structures proliferated and were able to acquire additional mutations, which led to intestinal neoplasia.

The genetic basis of the respective mutations which led to enhanced cellulase production in these industrial strains is essentially unknown.

This patient displayed serious clinical features given that she had compound truncation mutations, which led to hepatic AGT deficiency.

For 7 abcc6 missense mutations which led to mislocalization of the abcc6 transporter but with intact transport activity, 4-PBA could restore the plasma membrane localization in 4, confirming in vivo what was previously shown in vitro in mouse liver tissues [ 20].

Many of the mutations, which lead to these characteristics, will confer a survival benefit on the mutated cells, and lead to clonal expansion at the expense of other cells.

X-ray repair cross-complementing group 3 (XRCC3) is responsible for maintaining the integrity of the genome, playing a critical role in protecting it against mutations which lead to cancer.

Subtype 6.1 specifically deals with dysregulation of PTEN in the absence of BRAF mutations which leads us to consider AKT/PI3K inhibitors as potential therapies for this subtype.

Subtype 6.2 specifically deals with dysregulation of Akt in the absence of BRAF mutations, which leads us to consider AKT/PI3K inhibitors as potential therapies for this subtype.

The WS genotype is not static either, as WS genotypes are known to accumulate measurable metabolic defects and reduced fitness within 100 generations, whilst compensatory adaptation (mutations which lead to an increase in fitness) in WS lineages has been seen within a similar interval in liquid microcosms [25].