Sentence examples for mutants which led from inspiring English sources

These findings suggested that muscle cells are present and correctly localized but internally disorganized in y241 mutants, which led us to examine the subcellular architecture of myofibers.

The T331A mutant was consistently more prone to open than WT and any other mutants, which led to the occasional simultaneous opening of several monomers.

Eveleigh prepared two separate lines of mutants which led to the hypercellulolytic strains RUT C30 and RL-P37 ([ 5]; Fig. 1), of which H. jecorina RUT C30 has become the most frequently used strain for laboratory cellulase production [ 6- 11].

For instance, it was observed that azole fungal antibiotics could in fact restore viability in specific sterol auxotrophic mutants, which led to the discovery that the endogenously synthesized lanosterol can substitute for ergosterol (Gachotte et al. 1997).

Drosophila emerged as the premier study system for genetics because of naturally occurring visible mutants, which led to the discovery of chromosomal heredity, while Caenorhabditis was selected as the main organism for studies of cell differentiation and development because its cell lineage is nearly invariant from egg to adult.

The findings indicated that pc/glis3 is involved in PKD and that the mutation in pc mutants, which leads to the truncation of some zinc fingers and the C-terminus, results in a loss of function in the pc/glis3 protein.

The idea is that Yrt negatively regulates Crb by interacting with its FBM directly, and yrt mutants (which leads to Crb over expression) or UAS-Crb over-expression in the AS produces similar DC defects.

Because csn1Δ, ddb1Δ and cdc22-M45 mutants, which lead to insufficiency of dNTPs, all showed the same phenotype, we concluded that the prolongation of nuclear movements resulted from stalled DNA replication in meiosis.

The exception in this region was the W36A mutant, which led to a 50% level in both Aβ species, possibly due to a change in the anchoring of the bottom of TMD1 with the lipid water interface and thereby allowing F37/38 to form part of the transmembrane domain.

We found that none of the single mutations had an observable effect on the MIC value of any substrate tested, whereas the maximum detrimental effect was observed for the triple mutant, which led to a 32-fold reduction of MIC for Nov and TPP.

The increased neddylation in the K472E/R473E Cul1 mutant, which leads to the disruption of a buried salt bridge in the four-helix bundomainmain of Cul1 [24], is likely a result of reduced binding of the deneddylating CSN complex (see Fig. 2b).