Sentence examples for variants which led from inspiring English sources

From this list, we excluded all the synonymous variants, which led us to a final number of 25 variants (Supplementary Material, Table S1).

Here, we report an approach that focuses on fine-tuning anticodon recognition of MjtRNACUATyr by MjTyrRS variants, which led to additional improvement in unAA incorporation efficiency beyond the EF-Tu strategy.

Fig. 2 Number of SSM-BSLA variants which lead to improved/unchanged/decreased organic solvent resistance and inactivation of BSLA in buffer.

The sporadic expansion of retrotransposons can also introduce genomic/phenotypic variants, which lead to speciation in the long evolutionary terms [ 5, 6].

Another hypothesis, one consistent with the patient's rapid demise, is infection with a particularly virulent HIV variant, which led to rapid immunocompromise and failure of seroconversion.

Of 100 such clusters examined by one author (DW), 6 (6%) were thought to represent two individuals, while the rest were thought to represent one individual, with a variety of variants of identifiers, name variants etc which led to false positive classification.

With the technology and analytic tools now in place, and motivated by successes such as the identification of low-frequency coding variants in PCSK9, which led to the development of new therapies to treat hypercholesterolemia [ 7- 9], RVASs are starting to characterize (and quantify) the contribution of rare variants to human phenotypic variation.

(2) The learned features have shift variant properties, which leads to the misclassification of mechanical health conditions.

Whole exome sequencing (WES) in an Ashkenazi Jewish Israeli RP patient revealed a novel homozygous HGSNAT variant, c.370A>T, which leads to partial skipping of exon 3. Screening of 66 Ashkenazi RP index cases revealed an additional family with two siblings homozygous for c.370A>T.

One regulatory SNP is thought to act as a low-penetrance cancer susceptibility factor in its own right: homozygosity for the intronic 309T>G MDM2 variant (rs2279744), which leads to enhanced binding of the Sp1 transcription factor and MDM2 up-regulation, appears to increase the risk for many types of tumour, presumably in concert with other lesions (Hu et al. 2007).

This notion was further supported by the fact that introduction of another electrophilic group, an epoxide, at this position into 'MonoRed A', which led to the variant 'Bisepoxide', restored its bioactivity.