Sentence examples for mutations that target from inspiring English sources

The digestive capacity of SI can be affected by primary genetic mutations that target the SI gene.

There is clear genetic evidence for a central role for both of these enzymes in tumorigenesis: somatic mutations that target PTEN and the α catalytic subunit of PI3K (pi3kcareare frequent occurrences in human cancer, resulting in increased activity of the PtdIns 3,4,5 P3 signaling pathway [50].

Oncogenes are typically activated by missense mutations that target specific key residues of the protein.

Mutations that target the evolutionarily conserved catalytic domain of the protein are predicted to impair its function.

Strikingly, we identified cancer patient-derived oncogenic p85α mutations that target the homodimerization or PTEN interaction surface.

First, despite its frequent co-deletion with CDKN2A, germline or acquired mutations that target CDKN2B exclusively have not been observed [ 49, 50].

Thus, we have documented a somatically acquired gene-specific inactivating mutation that targets MYBL2 in one case of MDS.

We therefore searched our in-house endometrial cancer data set (Cheung et al., 2011) and The Cancer Genome Atlas (TCGA) (Cerami et al., 2012) for cancer patient-derived PIK3R1 mutations that could target p85α homodimerization.

These observations suggest that in addition to LOH, promoter methylation, and the APC mutations, miRNAs that target APC may regulate the aberrant activation of the canonical WNT signaling pathway for the initiation of human breast cancers, the enhancement of niche independence, and the aberrant proliferation of the human BCSCs.

Our genotyping panel included most gene mutations that are targeted by new drugs in ongoing clinical trials.

So, pol IV could have been responsible for the double mutations that included targeted T deletions, which was noted for the single-point mutations.