Most mutations that confer resistance to imatinib are distributed throughout the Abl kinase domain.
Mutations that confer higher levels of resistance to SP did not emerge.
In addition, we identify mutations that confer species-specific resistance, or antifolate-specific resistance.
What is less well understood is the evolutionary history of the mutations that confer drug resistance in the H5N1 population.
Scientists have since found other genetic mutations that confer resistance to Gleevec, and companies are now using such information to design drugs to overcome that resistance.
Additionally, we mutate the target of the cancer therapeutic bortezomib, PSMB5, and identify known and novel mutations that confer bortezomib resistance.
For example, we are now able to prevent often occurring mutations that confer antibiotic resistance and ask, which other genetic changes could lead to the same result.
What is needed are tests capable of diagnosing drug resistance within 24 hours — tests that do not require letting the bacteria grow in culture for days but rather identify gene mutations that confer drug resistance.
However, antibodies bind only to a single epitope, and mutations that confer resistance to antibody-mediated inhibition of HIV entry have been detected.
Mutations that confer substantial risk for schizophrenia have been identified at several loci, most of which have also been implicated in other neurodevelopmental disorders, including autism.
Multiple studies have described a reduction in the replicative fitness of HIV-1 isolates harboring mutations that confer resistance to antiretroviral drugs.
