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Unlike traditional genetic links to disease, the variants are not mutations that destroy a gene's function.
It is caused by mutations that destroy the function of a gene that is needed to make T cells, a class of white blood cells.
Evolution is a game of 'use it or lose it', and genes that do not aid an animal's survival or reproduction are liable to build up random mutations that destroy their ability to make a working protein.
Most of the 13 mutations that destroy interactions with both Nse1 and Nse4 change residues that are buried inside the Nse3 molecule (Fig. 3A).
These models yield different consequences of mutations that destroy splicing sites.
Mutations that destroy promoter or regulatory sequences can result in the "silencing" of transcription or translation or premature termination of protein synthesis [ 4].
Similar(49)
Individual G0 embryos were tested by PCR and restriction fragment length polymorphism using tmem33ex3F and tmem33ex3R primers (Table S1), to identify somatic mutations that destroyed the EcoNI restriction site.
When they sequenced it, they found the mutation that destroyed its function.
They scrutinized genetic data from a federal study and found that about 2.5percentt of blacks had a mutation that destroyed one copy of the gene; 3.2percentt of whites had a mutation that hobbled a copy of the gene but did not destroy it.
The known A→G transition mutation that destroys an AflIII restriction enzyme recognition site was detected by RFLP analysis.
Of the 54 identified addition genes, 9 were caused by a point mutation that destroyed the stop codon and 45 were caused by a frameshift mutation upstream of the stop codon.
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mutations that occur
mutations that allow
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mutations that are
mutations that improve
mutations that have
mutations that indicate
mutations that start
mutations that seem
mutations that make
mutations that change
mutations that promote
mutations that carry
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mutations that introduce
mutations that extend
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