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Such work is revealing opportunities to find genetic mutations that exist in multiple kinds of cancers and suggests the potential for applying therapies proven for one type of cancer to treating cancers of other types.
The frequency spectrum is a count of the number of mutations that exist at a frequency of xi = i/n for i = 1, 2,.., n−1, in a sample of size n.
Future studies that would allow for reporting on linked mutations that exist in one coding region, or linked mutations in different coding regions in pol, will require some means of associating individual pyrosequencing reads.
On the other hand, mutations that exist in the PRNP gene might facilitate the development of TSEs [ 3- 5].
Research studies must be performed to assess the relevance of a priori important mutations that exist within a minor tumour subclone.
Suppressive therapy is assumed to be a regimen against which the single mutations that exist in all infected individuals do not confer resistance, such as triple-drug highly active antirectroviral therapy (HAART).
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Second, mutations in regenerant plants might reflect somatic mutations that existed in the cells of the initial root explant prior to in vitro regeneration, with these somatic mutations comprising a molecular mutational spectrum differing from that of spontaneous "germline" mutations.
Old wars never die Budding greens Fast foes Keith Colquhoun Splittism on the roof of the world Correction: Tibet ReprintsThere, they say, the mutation that existed in under a tenth of the population spread to nearly nine-tenths because those with it survived far better than those without.
It can be very challenging to discern whether a read of a low allele fraction represents a true mutation that exists within a subset of tumor cells or is an artifact that should be discarded.
The challenge however, is to accurately model the errors in the sequencing data and differentiate real viral mutations, particularly those that exist at low frequencies, from sequencing errors.
Finally, the genetic mutations that already exist in the tumour cell of origin are sometimes forgotten.
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Justyna Jupowicz-Kozak
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