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Among the recessive lethal mutations that survive until 1950, we expect that 19% will have been exposed in homozogote(s) and thus, in expectation, 8.1% of all recessive lethal mutations carried by the founders will have manifested themselves to date.
In addition, while we ignore interference and linkage between recessive lethal alleles when simulating the transmission of those mutations, this should not influence the mean proportion of mutations that survive or manifest themselves, so will not bias our estimate of the probability of manifestation.
This observation points to the underlying variation as the determinant of sup: we infer that those sterile mutations that survive and accumulate occurred in cells already more fit than most of the population as the result of the accumulating background genetic variation.
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In very early discussions, Fisher suggested that many mutations had already occurred and the observed wild-type phenotypes were in fact those mutations that survived and that complete dominance would generally be regarded as a product of selective modification.
Then, the probability that a given infection of biomass v contains a resistant mutation that survives in the blood stage is (10) Further details are given in Appendix C. In the Results section, we focus on blood-stage emergence using the dynamic model only.
They reply: Those that survive!
The manuscript by Funt and colleagues provide an in-depth analysis of whole genome sequence of C. albicans progressively in HIV patients to infer selective events and describe patterns of mutations, and those that survive and likely have an impact on resistance.
Response to specific comments: The manuscript by Funt and colleagues provide an in-depth analysis of whole genome sequence of C. albicans progressively in HIV patients to infer selective events and describe patterns of mutations, and those that survive and likely have an impact on resistance.
Single nucleotide polymorphisms (SNPs), insertions, and deletions in a natural population of flies are mutations that have survived the filter of natural selection and can be tested via genome-wide association (GWA) for effects on genetic variation in sleep [ 20].
But because bacteria often develop resistance gradually by undergoing a series of mutations, the drug company counted those that survived levels of drug just 2 times what's normally deadly.
For intermediate migration rates, the potential of invasion is elevated by linked selection; this is mainly due to a substantially increased mean extinction time of those still rather few mutations that successfully survive the initial phase of stochastic loss.
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