Sentence examples for mutations that emerge from inspiring English sources

Serial analysis of individual CTCs isolated from blood samples taken over the course of treatment may be used to identify new mutations that emerge in response to therapy which influence disease progression or therapeutic resistance [88], enabling oncologists to alter treatment accordingly.

It is therefore important to assess, firstly, the risks for transfer of OC resistance mutations that emerge in avian influenza virus into influenza virus spreading in the human population, and, secondly, the possible influence of this phenomenon on treatment efficiency.

Among older adults NoV GII.4 is the most predominant genotype in outbreak, inpatient, LTCFs and community settings, potentially due to a combination of novel GII.4 mutations that emerge (such as the insertion of an amino acid in recent GII.4 strains) and limited immune response among older adults due to immunosenescence [ 35, 38, 66, 90, 97].

We evaluated the impact of the HA mutations that emerged during passaging in ferrets in a modified turkey red blood cell (TRBC) assay (Table 2).

Here we discuss two mutations that emerged from an in vitro selection experiment designed to improve the folding stability of a non-biological ATP binding protein.

A unique pattern of NRTI-associated mutations that emerged when failing rilpivirine was M184I or M184V/I mixtures.

We did not fully characterize the T191I NA mutation that emerged in our 2nd selection experiments, but based on observation that this amino acid is located far from the NA active site we expect that this mutation likely affects NA activity by reducing NA incorporation into virions, rather than directly altering enzymatic activity.

Several lines of evidence indicate that TW10 is the most important target determining the viral load set point: TW10 is the earliest target during primary infection [32]; and among all the described HLA-associated mutations, T242N is the earliest escape mutation that emerges during acute infections [13].

A resistance analysis from THRIVE and ECHO demonstrated that the most common NNRTI-resistant mutation that emerged when subjects failed rilpivirine was E138K (77%), and K103N (57%) in subjects who failed efavirenz.

These included JI281, WL1771, the argenteum mutant [also a spontaneous mutation that emerged in a breeding line belonging to L.G. Cruger, with an unknown background (Marx 1982)] and the cultivars Cameor, Champagne, Kaliski, Torsdag (Hobart Line 107) and Virtus.

The original wilty line resulted from a spontaneous mutation that emerged in a breeding line belonging to L.G. Cruger from Del Monte Corporation, San Lenadro, CA, and was later sent to Prof. G.A. Marx in the early 1970s (Marx 1976).