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Exact(9)
In the disease, mutations prevent the three genes from working.
As reported previously [8], many of these mutations prevent the localization of MeCP2 to densely methylated heterochromatic foci and give diffuse staining in fixed cells (Figs. 1, left).
Five mutations prevent the expression of both the Secteur and Anneau, either spontaneously or after inoculation.
These mutations prevent the activation of caspases-8, -9, and -3 and result in the derepression of Bcl2.
We have also shown that these mutations prevent the cellular redistribution of Perforin-2 in response to LPS.
4, 20 These mutations prevent the ability of the channel to distinguish between K+ and Na+ ions.
Similar(51)
However, the two models display distinct synaptic and behavioral alterations and it would thus be interesting in future studies to examine the consequences of mutations preventing the expression of both proteins.
In silico modelling suggested that the mutations prevented the compounds from binding the VP1 pocket in the capsid.
These 'differentiated' cells normally silence the gene that encodes TERT, but the mutations prevented the gene from being silenced.
To explore these processes in vivo, Cottee et al. studied mutant fruit flies in which the interactions between CPAP and STIL were weaker than normal, and found that these mutations prevented the normal formation of centrioles.
Ashlyn's mutation prevents the gene from making the channel, and the electrical impulses are never produced.
Related(20)
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