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MUTATIONS are the ultimate source of genetic variation that natural selection acts upon.
"Spontaneous mutations are the motor of evolution," Dr. Lagoda said.
The observed dG·dC→dT·dA transversion mutations are the result of base shifting and tautomerization.
Certain of these mutations are the targets of a new generation of specially designed drugs.
The breast cancer gene mutations are the latest case in point and the fastest growing area of testing.
C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
SPAST mutations are the most common in Chinese AD-HSP followed by ATL1.
In both sexually and asexually reproducing species, mutations are the single most important source of genetic variation.
Occasionally, bases are changed in a way that increases the survival or reproductive success of their carrier: such mutations are the basis of adaptation by natural selection.
Presenilin 1 (PSEN1) mutations are the main cause of monogenic Alzheimer's disease.
Bacteria that have all five mutations are the most resistant, while bacteria with none are very susceptible to the drug.
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