Sentence examples for mutations perturb the from inspiring English sources
While the protein is still in the native state and therefore functional, the studied mutations perturb the conformational dynamics.
To determine whether the elo null mutations perturb the localization of WT α-syn, fluorescence microscopy was conducted using a green fluorescent variant of WT α-syn (EGFP-WT-α-syn) after a 6 h induction.
These data support a model in which LMNA mutations perturb the intranuclear positioning and compaction of chromosomal domains and provide a mechanism by which gene expression may be altered.
The drug-induced protease mutations perturb the mechanistically crucial hinge axes that involve key sites for substrate binding and dimerization and mainly coordinate the intrinsic dynamics.
Another key finding in our experiments is that Fbxl7 mutations perturb the distribution of D around the perimeter of the apical region of the cell.
If the mutations perturb the dynamics of RyR2, making the release of the kinase more difficult, they would result in overphosphorylation, which is the known signature of the disease.
Yet cells seem to be able to maintain their normal functions despite many perturbations, such as the gene knock-out or DNA mutations perturbing the functions of proteins, while being sensitive to some specific attacks (Jeong et al., 2001).
In addition, it was shown in NH3T3 cells, that neither mutations in the RING finger nor the linker region causes transformation, however while certain mutations perturbs the ubiquitination, others affect receptor recycling and prolong kinase activity [28].
We can only bring these MC values down by mutations perturbing the machinery of chromosomal organization.
NMR and biochemical analyses indicate that the IgFLNa20 21 domain pair inhibits integrin β-tail binding and mutations perturbing the IgFLNa20 21 interaction enhance integrin binding.
From docking analysis of ALK with crizotinib, it is well revealed that both the mutations perturbed the binding pocket quite significantly.
