Sentence examples for mutations may render from inspiring English sources

However, the high frequency of GNAQ mutations may render it a promising target for therapeutic intervention.

Accumulation of unfavourable mutations may render a coding region nonfunctional, facilitating its removal from the genome in course of time.

Some of the mutations may render the toxin dysfunctional, leading to decay of the TA system as previously studied for the ccdO157 system.

Once a patient presents with progressive or recurrent disease, these mutations may render the tumour insensitive to platinum-based chemotherapy irrespective of the PTEN status.

In addition, particular oncogenic mutations may render a cell resistant to aging-associated insults, such as chronic inflammation that promotes cellular senescence or apoptosis due to increased reactive oxygen species (ROS) production.

To rule out the possibility that the deletion and mutation may render detrimental effect on the overall structure of the M protein and its interaction with other viral proteins that are essential for virion assembly, interaction of the Mm1 mutant with the E protein was tested by co-immunoprecipitation.

Furthermore, the severity of the telomerase mutation may render cells completely unable to re-elongate telomeres.

CDO504 copy B showed a different pattern, possessing several frameshift mutations that may render the protein product non-functional.

The ycf1 gene in A. evecta contains a frameshift mutation that may render it nonfunctional, or it may retain functionality as a split gene with two protein products [ 18].

As such, mutations in ARID2 may render IFN-related immune processes incapacitated in the setting of HCV infection, leading to accelerated tumorigenesis.

Although the presence of PBPs per se does not confer resistance, chromosomal mutations in PBPs may render the bacteria resistant to β-lactams [ 72- 75].