Sentence examples for mutations may exist from inspiring English sources

First, our approach focused on the exome, examining 1.22% of genome, and additional mutations may exist outside these regions.

Therefore, the genetic cause of a recessive disease may not even be suspected in many cases, and more recessive mutations may exist than realized.

It has been suggested previously that resistance-conferring mutations may exist in the tumor prior to therapy (Gerlinger & Swanton, 2010; Diaz et al, 2012).

When many types of mutations may exist within an amplicon, as in the case of KRAS exon 2, it is difficult to assign a melting profile to each one, even more so if, as we observed, the pattern varies with the amount of the mutant allele.

In this family, we did not observe any mutations in the known FHM genes, although an unknown mutation may exist.

The occurrence of the resistant allele in both the dead and alive specimens suggests that kdr mutation may exist with another factor necessary for the expression of the resistance phenotype, and resistance could also be multigenic as a result kdr may not fully explain all the variance in phenotype [48], [51] [52].

However, other populations that might obtain a clinical benefit from gefitinib treatment, even in the absence of EGFR mutation, may exist.

It is also conceivable that the N370S mutation may exist only in specific areas of China and/or some other Asian regions.

Emerging evidence suggests that the T790M 'gatekeeper' mutation may exist in lung tumours before EGFR-TKI therapeutic selection (Bell et al, 2005; Godin-Heymann et al, 2007), partly due to its enhanced oncogenicity, and accounts for the adverse clinical course and outcome in gefitinib/erlotinib-resistance lung cancers after a course of rapid TKI selection.

However, the present study suggests that application of these methods alone fails to detect novel MYD88 mutations that may exist in WM and might even misdiagnose WM patients lacking MYD88 L265P.

Such mutations may be hypothesized to exist in the dhps gene itself, in loci which mediate DHPS expression and thereby parasite fitness in the presence of drug, or in heretofore undescribed mediators of pathogenesis.