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Exact(9)
Alleviation of this metabolic checkpoint in type 2 by p53 mutations may allow progression to eosinophilic ChRCC, indicating that they represent higher risk.
We sought to test the hypothesis that a comprehensive, unbiased analysis of somatic mutations may allow for an improved classification of these diseases to predict outcome (overall survival).
Other mutations may allow normal assembly, but affect the thermodynamics or kinetics of gating resulting in impaired ability to adapt to changes in heart rate.
Severely destabilizing mutations are expected to dramatically impair the function of pVHL while less destabilizing mutations may allow partial preservation of pVHL's function.
This may provide direct evidence of positive and negative clonal selection and the detection of emerging clones carrying drug-resistance mutations may allow early modification of treatment strategies before clinical progression occurs.
Recent retrospective data have suggested that EGFR amplification or KRAS exon 1 somatic mutations may allow a better selection of patients who are candidates for EGFR targeting [ 12, 13].
Similar(51)
The second hypothesis is that linkage between mutator alleles and beneficial alleles arising though mutation may allow females to continuously select more viable males as expressed in their condition-dependent secondary sexual characters.
Recently, the identification of the possible disease-defining BRAF V600E mutation may allow the development of new therapeutic targets.
We speculate that this mutation may allow the expression of an innexin that can substitute for EAT-5 in coupling the corpus to the TB.
It is difficult to envisage though, how a mitochondrial mutation may allow an acute increase in buffering; if anything, the opposite might be expected.
We have argued before that, if MG3 U is very small, then a U at the wobble site of tRNA anticodon would impose little selection against G-ending codons in NNR codon families, and mutation may allow NG to drift up, leading to large NG values relative to NA.
Related(20)
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