Sentence examples for mutations for functional from inspiring English sources

Our data indicate that TRV and PEBV can facilitate plant genome engineering and can be used to produce targeted mutations for functional analysis and other biotechnological applications across diverse plant species.

Interestingly, hANT4 required additional mutations for functional expression in yeast mitochondria.

Until now the functional role of mtDNA mutations for functional and structural changes of aged skin is not understood.

Homologous recombination in E. coli has been used for the modification of BAC inserts to introduce reporter genes or subtle mutations for functional analysis (reviewed in [ 4]).

These would give user clear understanding of the relative stability of protein protein interaction sites and would be of predictive value in designing point mutations for functional analysis.

This is biologically significant because it allows us to prioritize mutations for functional studies and offers insight into structure function relationships for IRF6 and other members of this highly conserved family of transcription factors.

B) We therefore examined clonality data to determine the earliest event in this class (and therefore possibly the initiator of genomic instability, leading to subsequent genomic deletions), which prioritized SPOP mutation for functional study.

This scoring system with some minor modifications was tested using previously described pathogenic mutations, for which functional studies had been performed, as positive controls, and known neutral variants or polymorphisms as negative controls.

To determine whether perturbation of any given gene in a genome suffices to drive subsequent genetic changes, we analyzed the yeast knockout collection for secondary mutations of functional consequence.

Also, it remains an unanswered question as to whether the mutant stocks with single gene mutations are suitable for functional genomics studies of complex phenotypes, which are controlled by many genes and influenced by the environment (Li et al. 2005).

In addition to polymorphisms that are simply associated to causative mutations, those responsible for functional differences that directly contribute to disease are of greater importance.