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Since it appears that functional sites can sometimes occur in many different locations among related domains, relying too strictly on homology transfer for functional site prediction may sometimes result in missing potentially interesting predictions.
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By incorporating similarity at both the sequence and the network level, we compute alignments that allow for the transfer of functional annotation as well as for the prediction of missing interactions.
Subnetworks with shared interactions across species allow for improved transfer of functional annotations from one species to the other by using more information than sequence alone [ 2].
Human Artificial Chromosomes (HACs) are potentially useful vectors for gene transfer studies and for functional annotation of the genome because of their suitability for cloning, manipulating and transferring large segments of the genome.
For transferases (which catalyze transfer of functional groups from one molecule to another), the preferred metal cofactor was Mn.
Montecalvo, A. et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
The temporalis muscle is commonly used for functional transfer.
These GO terms are used for functional transfer and annotation.
The inserted plastid sequences of Rhazya include full-length protein-coding and tRNA genes, most of which are presumed nonfunctional, but some tRNA genes may be candidates for functional transfer as reported for wheat and potato [ 43, 44].
We believe that the semantic distance S2 provides more reasonable values for functional transfer, finding an optimal distance at 77, 88 and 78% for MFO, BPO and CCO, respectively.
However, studies of potential cancer stem cells from human solid tumors have some immanent problems due to the necessity of tissue processing before cell sorting and of transfer to another species for functional testing.
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