Sentence examples for mutations for many from inspiring English sources

The high EC50 value is problematic for measuring loss-of-function mutations for many reasons.

We have identified 428 mutation interactions in Specialty dataset with statistical significance and we were able to distinguish primary vs. accessory mutations for many well-studied examples.

The persistence of heteroplasmic mutations for many generations after their origin may lead to an inflated contribution to a pedigree-based estimate of mutation rate, if they are treated as mutations that have become fixed within individuals.

However, besides showing a temperature-sensitive phenotype, these bear a heavy cost to the cell (by affecting translation) in the absence of the antibiotic, a property common to resistance mutations for many classes of antibiotics.

Moreover, next-generation sequencing of large numbers of tumours across many tissue types is currently underway as part of the International Cancer Genome Consortium ICGCC) and The Cancer Genome Atlas (TCGA), and we can expect to have within a decade complete catalogues of somatic mutations for many of the most prevalent cancer types (www.icgc.org; http://cancergenome.nih.gov/).nih.gov/

Additionally, while the high prevalence and constitutive activation of MYD88L265P suggest that it is a gain-of-function driver mutation for many NHL, especially WM, the presence of other cytogenetic events may also mediate the development and progression of these diseases.

This approach was successfully applied in linkage studies of families to map the causal mutation for many mono-genetic diseases, and sets of several hundreds of genome-wide VNTR markers were sufficient to identify loci such as the BRCA1 locus or the cystic fibrosis gene locus.

As this is a highly differentiated region of the genome between individuals from the north and south of the distribution, it can in principle harbor the causative mutations responsible for many phenotypic differences between these populations.

Greater understanding of the evolutionary selection pressures on mtDNA will allow the construction of more accurate phylogenetic trees based upon mtDNA gene sequences [ 6, 7] as well as a better grasp of the root causes of mitochondrial DNA mutations responsible for many human diseases.

The mutation rate for many human recessive diseases is about 1 in 100,000 (u = 10−5).

FBN2 mutations are responsible for many cases of CCA [2] while mutation of the related gene FBN1 can result in Marfan's syndrome [1].