Sentence examples for variants for functional from inspiring English sources

This information could be further integrated with chromatin feature data for key cell types from the Human Encyclopedia of DNA Elements (ENCODE) project [31], with the ultimate goal of prioritizing non-coding risk variants for functional testing (e.g., by genome editing using CRISPR/Cas systems) [28,32].

The systematic approach allowed us to prioritize mtDNA sequence variants for functional analysis to establish pathogenicity.

The purpose of this approach is to help investigators in prioritizing mtDNA variants for functional analysis to establish pathogenicity.

However, these approaches harbor several major limitations that hinder the effective prioritization of variants for functional validation.

Replication of markers in 8q24 has been robust, but candidate variants for functional analyses remain elusive, especially in a region with a dearth of candidate genes.

This is not a unique situation and it makes choosing variants for functional characterization difficult considering the investment required for such comprehensive studies.

Finally, they will identify genetic variants responsible for functional phenotypes using cell-based in vitro model systems.

They were specifically designed to enable construction of asymmetrically-mutated variants suitable for functional studies.

For example, 2nd intronic Alu-exonized C-terminal variants code for functional isoforms, which were determined as new members of the reference protein (Liu et al., 2002; Wu et al., 2007; Yi et al., 2003).

The kinetic evidence that the electron transfer between the hemes bL takes place on a catalytically-relevant timescale came recently from the studies that used bacterial genetic systems to create asymmetrically-mutated variants suitable for functional studies.

This substantial fraction of the genome, for which we do not know the functional rules and constraints, could harbor variants for which functional assays need to be developed.