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Exact(7)
Recently, mutational studies of FtsY have revealed that site-specific mutations can modulate discrete conformational changes during Ffh·FtsY complex formation [23].
In each case, the data indicate the major pathways involved and the many ways that mutations can modulate those pathways.
These data imply that the ATP molecule and NRTI mutations can modulate nucleotide selectivity by altering the fidelity of the geometric selection of nucleotides and the probability of an excision reaction.
Our data support the notion that the ATP molecule and NRTI mutations can modulate nucleotide selectivity by altering the fidelity of the geometric selection of nucleotides and the probability of an excision reaction.
Our results illustrate that a wide-range of mutations can modulate the activity of many cellular resistance processes and demonstrate that E. coli has a large mutational target size for increasing antibiotic tolerance.
Our data imply that the ATP molecule and NRTI mutations can modulate the nucleotide selectivity of HIV-1 RT by influencing the geometric selection of nucleotides in the catalytic cavity, as follows: First, the presence of bound ATP molecule in the catalytic cavity can sterically influence the initial binding and translocation of dNTP/NRTI into the catalytic site.
Similar(53)
Alternatively, it was also shown that this mutation can modulate the potassium ion conductance by Kir6.2 [21].
However, our recent work conducted in Kenya provides evidence that a Ser160Asn/Thr mutation can modulate the parasite response to artemisinin combination treatments in vivo (10).
However, this is just an extreme case in the diverse spectrum of mutations that can modulate the formation of Alu exons.
We asked whether mutation in HY5 can modulate the JA sensitiveness of hy1 mutants.
The obtained data suggest that the ATP molecule and NRTI mutations can cooperatively modulate physicochemical properties of the p66 catalytic cavity to alter the fidelity of the geometric selection of nucleotides and the probability of an excision reaction.
Related(20)
mutations can modify
mutations can alter
variants can modulate
mutations can vary
mutations can influence
mutations can regulate
mutations can work
mutations can slow
mutations can show
mutations can improve
mutations can cost
mutations can block
mutations can opt
mutations can extend
mutations can confer
mutations can pass
mutations can warp
mutations can interfere
mutations can arise
mutations can occur
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