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These allosteric mutations can work through 'AND' all-or-none or incremental 'Graded' logic gate mechanisms.
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It showed that in addition to a single distal histidine with a suitable distance to the heme iron (Phe43 to His43 mutation), a second distal histidine (Leu29 to His29 mutation) can work cooperatively to increase the turnover number, mimicking the role of well-known His-Arg pair in native peroxidases.
Mutations can make it impossible for a cell to make a protein from a gene.
Even through the maturation process, mature antibodies can exist in an equilibrium of two or more structural isomers, only one of which is the binding conformer; stated differently, mutations that accumulate during antibody maturation can work cooperatively to narrow conformational ensembles (Foote and Milstein, 1994, Manivel et al., 2000, Zimmermann et al., 2006).
In other words, the algorithm can work on lists of single mutations.
However, both mechanisms can work in parallel alongside each other, which provides extra protection against nonsense mutations.
Of course, gene conversion can work in both directions; that is to say, the process can spread a mutation or reverse it.
This argument can work.
Yet it can work.
"We can work.
We can work together".
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