Sentence examples for mutations can confer from inspiring English sources

c Driver gene mutations can confer an advantage in the founder clone and promote subsequent expansion.

This is because only one specific mutation can lead to cross-resistance, while many mutations can confer resistance against only one drug.

These results establish that H. pylori Fur's distinctive N terminal arm is functional, and more generally illustrate that point mutations can confer informative phenotypes, distinct from those conferred by null mutations.

BARD1 mutations can confer cancer susceptibility, but larger studies are essential to confirm that.

Their studies aimed to determine whether disease-associated ALK mutations are universally gain-of-function and whether certain ALK mutations can confer resistance to tyrosine kinase inhibitors.

This effect is specific to bulk selection approaches and is likely to occur for all phenotypes for which single mutations can confer a significant growth advantage.

Building on this background, our study further suggests that a single mutation can confer both temperature-sensitive gain-of-function (i.e. action potential generation at higher input currents) and loss-of-function (i.e. lower action potential frequency) in Dravet syndrome.

In the late stages of progression, the mutation can confer an aggressive cancer phenotype.

This finding suggests that oxidative modifications of C361 can reversibly modulate the assembly of the ternary complex and that a C361A mutation can confer redox-insensitivity to Brf2.

Despite several lines of preclinical evidence that either PIK3CA mutation can confer HER2 inhibitor resistance, a robust correlation of the occurrence of PIK3CA mutations with outcomes after trastuzumab or lapatinib therapy in patients is still lacking.

Nijnik et al. found that LIG4Y288C mice (a mouse model for human LIG4 syndrome) exhibit multiple defects in lymphocyte development and a hypomorphic LIG4 mutation can confer strong predisposition to lymphoid malignancies [ 30].