Sentence examples for mutation which abolishes from inspiring English sources

By contrast, the R133C mutation, which abolishes the selective recognition of methylated DNA, retains the chromatin compaction properties of the wild-type protein [30].

Not surprisingly, the colorectal cancer-associated R654Q mutation, which abolishes the D478-R654 salt bridge, should have a similar effect.

Second, the Rap1 mutationtation, which abolishes the Rap1-Sir3 interandion and slightly impairs telomeric silencing, has been shown to cause shortened telomeres (Feeser and Wolberger, 2008).

By contrast, introducing a second mutation, which abolishes DNA binding specificity, (Boer et al., 2014) (MPNm2-BSH), blocked activity of the fusion protein.

In this patient we identified a homozygous NOTCH3 nonsense mutation, which abolishes NOTCH3 expression and causes deregulation of NOTCH3 downstream target genes.

The discovery of the HQ mutation, which abolishes association of WNK isoforms, will be useful in future work to investigate further the physiological importance of this interaction.

Importantly, the individual L>K mutations which abolished β-catenin binding in vitro also eliminated association of BCL9 and B9L with β-catenin in vivo, so HD2 is the only domain through which these proteins can bind to β-catenin in cells.

This interaction is mediated by a CxVxL motif specific to the long isoform, mutation of which abolishes interaction and colocalisation with dHP-1a.

Hr N mutants harbor the mutation A402G, which abolishes the same uATG as in Hr Hp mutants, indicating that they have an identical defect [ 16].

Resolution of this issue, as well as direct demonstration that NRP2 is required for SEMA3s action on lymphatic sprouting in vivo, will require Nrp2 mutant mice expressing Nrp2 with a mutation which selectively abolishes SEMA3s-NRP2 binding.

We generated a novel Lerp null mutation, Lerp F6, which abolishes LERP protein expression.