Sentence examples for mutation which converts from inspiring English sources
The Gln11Met mutation, which converts the signature glycine motif in PfMDH to that of PfLDH, did not change the enzyme function.
hU6 snRNA bearing a C62G mutation, which converts the C-U mismatch in U4/U6 stem II into a G-U wobble pair, supported only low levels of splicing (Wolff and Bindereif, 1993).
To examine whether Parkin forms an ubiquitin ester intermediate in neurons as well, we again used a lentivirus to express HA-Parkin with the C431S mutation, which converts an unstable ubiquitin thioester bond to a stable ubiquitin oxyester bond.
To generate E129K mutant Sco2 knock in (KI) mice a single base pair mutation, which converted nucleotide 385 in the mouse Sco2 sequence from G to A, was introduced by in situ mutagenesis.
To prospectively identify AR mutations that might confer resistance to enzalutamide, we performed a reporter-based mutagenesis screen and identified a novel mutation, F876L, which converted enzalutamide into an AR agonist.
Also the G141R mutation of PKCζ which converts the ζ-NLS into a ι-NLS, supports this notion since the construct mimicked the PKCι nuclear translocation kinetics exactly (higher maximum, reached after 2 hours LMB treatment).
Protooncogenes can be altered by mutation or epigenetic modification, which converts them into oncogenes and leads to cell transformation.
A missense mutation (c.346G>A) of TNSALP gene, which converts Ala to Thr at position 116 (according to standardized nomenclature), was reported in dominantly transmitted hypophosphatasia patients (A.S. Lia-Baldini et al. Hum Genet. 109 (2001) 99 108).
8a The minimal activation of Parkin by UbC46 is most likely attributable to the Ala46Cys mutation (which can be converted to the native Ala).
The arc2 mutation bears a single nucleotide substitution, which converts Ala-342 to Val in At2g28000.
The most common precore mutation abolishing HBeAg expression is G1896A, which converts the penultimate (28th) precore codon from TGG to TAG.
